1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]benzimidazole

Description

1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]benzimidazole : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	3238504
CHEMBL ID	1442619
CHEBI ID	108147

Synonyms (13)

Synonym
AKOS001139105
smr000024933
1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]-1h-benzimidazole
MLS000090323
CHEBI:108147
STK866912
1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]benzimidazole
HMS2168K17
HMS3320O22
CHEMBL1442619
Q27186772
1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]-1h-1,3-benzodiazole
Z57369870

Drug Classes (1)

Class	Description
benzimidazoles	An organic heterocyclic compound containing a benzene ring fused to an imidazole ring.

Protein Targets (20)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	11.0588	AID411; AID588342
glp-1 receptor, partial	Homo sapiens (human)	Potency	28.1838	AID624417
BRCA1	Homo sapiens (human)	Potency	11.2202	AID624202
ATAD5 protein, partial	Homo sapiens (human)	Potency	18.3564	AID504467
TDP1 protein	Homo sapiens (human)	Potency	21.8370	AID686978; AID686979
Smad3	Homo sapiens (human)	Potency	35.4813	AID588855
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	4.4668	AID720542
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	25.1189	AID926; AID938
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	2.8184	AID2326
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	3.1623	AID485313
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	12.5893	AID902; AID924
chromobox protein homolog 1	Homo sapiens (human)	Potency	79.4328	AID540317
ras-related protein Rab-9A	Homo sapiens (human)	Potency	5.6234	AID485297
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	79.4328	AID2662
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	11.2202	AID2551
geminin	Homo sapiens (human)	Potency	32.6427	AID624297
Vpr	Human immunodeficiency virus 1	Potency	25.1189	AID651644
Integrin beta-3	Homo sapiens (human)	Potency	12.5893	AID924
Integrin alpha-IIb	Homo sapiens (human)	Potency	12.5893	AID924
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	50.1187	AID624287

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
albendazole	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator	low
astemizole	benzimidazoles; piperidines	anti-allergic agent; anticoronaviral agent; H1-receptor antagonist	low
cgp 12177	aromatic ether; benzimidazoles; secondary alcohol; secondary amino compound	beta-adrenergic antagonist	low
clemizole	benzimidazoles; monochlorobenzenes; pyrrolidines	histamine antagonist	low
domperidone	benzimidazoles; heteroarylpiperidine	antiemetic; dopaminergic antagonist	low
droperidol	aromatic ketone; benzimidazoles; organofluorine compound	anaesthesia adjuvant; antiemetic; dopaminergic antagonist; first generation antipsychotic	low
emedastine	benzimidazoles	anti-allergic agent; antipruritic drug; H1-receptor antagonist	low
fenbendazole	aryl sulfide; benzimidazoles; carbamate ester	antinematodal drug	low
lansoprazole	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	low
mebendazole	aromatic ketone; benzimidazoles; carbamate ester	antinematodal drug; microtubule-destabilising agent; tubulin modulator	low
nocodazole	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator	low
ns 1619	(trifluoromethyl)benzenes; benzimidazoles; phenols	potassium channel opener	low
omeprazole	aromatic ether; benzimidazoles; pyridines; sulfoxide		low
oxatomide	benzimidazoles; diarylmethane; N-alkylpiperazine	anti-allergic agent; anti-inflammatory agent; geroprotector; H1-receptor antagonist; serotonergic antagonist	low
oxibendazole	benzimidazoles; carbamate ester		low
pantoprazole	aromatic ether; benzimidazoles; organofluorine compound; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; environmental contaminant; xenobiotic	low
pimobendan	benzimidazoles; pyridazinone	cardiotonic drug; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent	low
rabeprazole	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	low
thiabendazole	1,3-thiazoles; benzimidazole fungicide; benzimidazoles	antifungal agrochemical; antinematodal drug	low
2-methylbenzimidazole	benzimidazoles		low
bendazole	benzimidazoles		low
2-aminobenzimidazole	benzimidazoles	marine xenobiotic metabolite	low
pimozide	benzimidazoles; heteroarylpiperidine; organofluorine compound	antidyskinesia agent; dopaminergic antagonist; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist	low
fuberidazole	benzimidazole fungicide; benzimidazoles; furans	antifungal agrochemical	low
2-Butyl-1H-benzimidazole	benzimidazoles		low
lobendazole	benzimidazoles; carbamate ester		low
carbendazim	benzimidazole fungicide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	antifungal agrochemical; antinematodal drug; metabolite; microtubule-destabilising agent	low
parbendazole	benzimidazoles; carbamate ester		low
benomyl	aromatic amide; benzimidazole fungicide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	acaricide; anthelminthic drug; antifungal agrochemical; microtubule-destabilising agent; tubulin modulator	low
ensulizole	benzimidazoles		low
flubendazole	aromatic ketone; benzimidazoles; carbamate ester; organofluorine compound	antinematodal drug; teratogenic agent	low
ciclobendazole	benzimidazoles; carbamate ester		low
oxfendazole	benzimidazoles; carbamate ester; sulfoxide	antinematodal drug	low
liarozole	benzimidazoles		low
bendamustine	benzimidazoles		low
propazole	benzimidazoles		low
mizolastine	benzimidazoles		low
cgs 9343b	benzimidazoles		low
telmisartan	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic	low
chlormidazole	benzimidazoles		low
2-amino-1-methylbenzimidazole	benzimidazoles		low
2-(1H-benzimidazol-2-yl)aniline	benzimidazoles; primary arylamine; substituted aniline	geroprotector	low
5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one	benzimidazoles		low
5-hydroxythiabendazole	benzimidazoles		low
5-hydroxymethylomeprazole	aromatic ether; benzimidazoles; pyridines; sulfoxide	drug metabolite	low
omeprazole magnesium	benzimidazoles; sulfoxide		low
omeprazole sulfone	benzimidazoles; sulfoxide		low
omeprazole sulfide	benzimidazoles		low
desmethylastemizole	benzimidazoles		low
bilastine	benzimidazoles		low
dabigatran etexilate	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; carboxylic ester; pyridines	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug	low
ilaprazole	benzimidazoles; sulfoxide		low
dabigatran	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; pyridines	anticoagulant; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; EC 3.4.21.5 (thrombin) inhibitor	low
N-butyl-1H-benzimidazol-2-amine	benzimidazoles		low
3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3]thiazin-3-ol	benzimidazoles		low
1-methyl-3-phenylpyrazino[1,2-a]benzimidazole	benzimidazoles		low
2-methyl-1H-pyrimido[1,2-a]benzimidazol-4-one	benzimidazoles		low
6-methyl-2-[(4-nitrophenyl)methylthio]-1H-benzimidazole	benzimidazoles		low
1-(phenylmethyl)benzimidazole	benzimidazoles		low
2-[[[2-methyl-1-(phenylmethyl)-5-benzimidazolyl]amino]methyl]phenol	benzimidazoles		low
2-(1H-benzimidazol-2-ylthio)-1-thiophen-2-ylethanone	benzimidazoles		low
2-(2-phenoxyethylsulfonyl)-1H-benzimidazole	benzimidazoles; sulfoxide		low
2-[[(6-bromo-1H-benzimidazol-2-yl)thio]methyl]-1-methylbenzimidazole	benzimidazoles		low
4-oxo-10H-pyrimido[1,2-a]benzimidazole-3-carboxylic acid ethyl ester	benzimidazoles		low
2-[[5-[2-(1H-benzimidazol-2-yl)ethyl]-4-methyl-1,2,4-triazol-3-yl]thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide	benzimidazoles		low
LSM-19079	benzimidazoles		low
1-(1-benzimidazolyl)-3-(1-cyclohex-3-enylmethoxy)-2-propanol	benzimidazoles		low
N-(3H-benzimidazol-5-yl)-2-furancarboxamide	benzimidazoles		low
2-[[3-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]acetic acid methyl ester	benzimidazoles		low
N-[1-[(4-methylphenyl)methyl]-2-benzimidazolyl]-2-furancarboxamide	benzimidazoles		low
11-[2-(4-morpholinyl)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrile	benzimidazoles		low
2-(1-benzimidazolylmethyl)-5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazole	benzimidazoles		low
N-[2-(3-acetamidophenyl)-3H-benzimidazol-5-yl]acetamide	benzimidazoles		low
N-[1-[2-(2-chlorophenoxy)ethyl]-2-benzimidazolyl]acetamide	benzimidazoles		low
N-[1-(2-methoxyphenyl)-5-benzimidazolyl]benzenesulfonamide	benzimidazoles		low
2-[2-(ethylthio)-1-benzimidazolyl]-1-(1-piperidinyl)ethanone	benzimidazoles		low
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide	benzimidazoles		low
2-(beta-D-glucosyl)benzimidazole	benzimidazoles; C-glycosyl compound		low
N-[1-(1-hexyl-2-benzimidazolyl)ethyl]-2-furancarboxamide	benzimidazoles		low
2-ethyl-1-[(2-methoxyphenyl)methyl]benzimidazole	benzimidazoles		low
2-(4-methoxyphenyl)-1-(2-methylprop-2-enyl)benzimidazole	benzimidazoles		low
2-[[(1-propan-2-yl-2-benzimidazolyl)amino]methyl]-6-prop-2-enylphenol	benzimidazoles		low
4-(1H-benzimidazol-2-ylmethylthio)-2-methylbenzofuro[3,2-d]pyrimidine	benzimidazoles		low
N-(3,4-dihydro-1H-[1,4]thiazino[4,3-a]benzimidazol-8-yl)pentanamide	benzimidazoles		low
N-(3,4-dihydro-1H-[1,4]thiazino[4,3-a]benzimidazol-8-yl)butanamide	benzimidazoles		low
N-[2-(2-benzamidoethyl)-1-methyl-5-benzimidazolyl]-2-furancarboxamide	benzimidazoles		low
3-(1-benzimidazolylmethyl)-6-[(4-methoxyphenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	benzimidazoles; triazolothiadiazole		low
2-methoxy-1-(1-methyl-2-benzimidazolyl)-1-phenylethanamine	benzimidazoles		low
N2-(1H-benzimidazol-2-yl)benzene-1,2-diamine	benzimidazoles		low
2-[(2-ethoxy-2-oxoethyl)thio]-1-benzimidazolecarboxylic acid ethyl ester	benzimidazoles		low
6-methyl-2-(trifluoromethyl)-3,5-dihydroimidazo[4,5-f]benzimidazole	benzimidazoles		low
3,4-dimethyl-N-[[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]-sulfanylidenemethyl]benzamide	benzimidazoles		low
4-[1-[(3-methoxy-4-methylphenyl)methyl]-2-benzimidazolyl]-1,2,5-oxadiazol-3-amine	benzimidazoles		low
1-ethyl-2-[[(1-methyl-2-benzimidazolyl)thio]methyl]benzimidazole	benzimidazoles		low
2,6-bis(benzimidazol-2-yl)pyridine	benzimidazoles		low
N,N,2-trimethyl-1-phenyl-5-benzimidazolesulfonamide	benzimidazoles		low
4-[2-(1-methyl-2-benzimidazolyl)ethyl]aniline	benzimidazoles		low
5,6-dimethyl-2-[2-(1-pyrrolidinyl)ethylthio]-1H-benzimidazole	benzimidazoles		low
2-[(2-methoxyphenoxy)methyl]-1H-benzimidazole	benzimidazoles		low
4-(1-ethyl-2-benzimidazolyl)aniline	benzimidazoles		low
3-(2-phenoxyethyl)-1H-benzimidazole-2-thione	benzimidazoles		low
N-[1-(4-methylphenyl)-5-benzimidazolyl]acetamide	benzimidazoles		low
2-(1H-benzimidazol-2-ylthio)-N-(5-propyl-1,3,4-thiadiazol-2-yl)acetamide	benzimidazoles		low
4-[(1H-benzimidazol-2-ylthio)methyl]-2-thiazolamine	benzimidazoles		low
3-[2-(4-methyl-2-propan-2-ylphenoxy)ethyl]-1H-benzimidazole-2-thione	benzimidazoles		low
4-methyl-N-[1-[2-(1-pyrrolidinyl)ethyl]-2-benzimidazolyl]benzamide	benzimidazoles		low
1-ethyl-2-[(4-methylphenoxy)methyl]benzimidazole	benzimidazoles		low
2-(2,5-dimethylphenyl)-3H-benzimidazol-5-amine	benzimidazoles		low
(2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine)	benzimidazoles		low
N-(2-furanylmethyl)-1-(4-methoxyphenyl)-5-benzimidazolamine	benzimidazoles		low
N-(1-propyl-5-benzimidazolyl)-2-thiophenecarboxamide	benzimidazoles		low
N-(1-tert-butyl-5-benzimidazolyl)-2-thiophenecarboxamide	benzimidazoles		low
2-(3-methyl-2-oxo-1-benzimidazolyl)acetonitrile	benzimidazoles		low
6-(1H-benzimidazol-2-yl)-2-methyl-1H-benzimidazole	benzimidazoles		low
1-[2-(2-chlorophenoxy)ethyl]benzimidazole	benzimidazoles		low
1-ethyl-N-[(4-methoxyphenyl)methyl]-5-benzimidazolamine	benzimidazoles		low
5-(1-methyl-2-benzimidazolyl)-2-thiophenecarboxaldehyde	benzimidazoles		low
2-(1H-benzimidazol-2-ylmethyl)benzene-1,4-diol	benzimidazoles		low
1-[(3-methylphenyl)methyl]benzimidazole	benzimidazoles		low
1-(2-methylpropyl)-2-thiophen-2-ylbenzimidazole	benzimidazoles		low
N-(1,3-dimethyl-2-oxo-5-benzimidazolyl)-2-benzofurancarboxamide	benzimidazoles		low
N-(2-ethoxyphenyl)-1H-benzimidazol-2-amine	benzimidazoles		low
N-cycloheptyl-2-[(6-nitro-1H-benzimidazol-2-yl)thio]acetamide	benzimidazoles		low
2-methyl-N-[2-[1-[2-(4-methylphenoxy)ethyl]-2-benzimidazolyl]ethyl]propanamide	benzimidazoles		low
N-(1-tert-butyl-5-benzimidazolyl)-3,4,5-trimethoxybenzamide	benzimidazoles		low
N-[2-(2-pyridinyl)-3H-benzimidazol-5-yl]cyclohexanecarboxamide	benzimidazoles		low
N-[2-(3-pyridinyl)-3H-benzimidazol-5-yl]-2-furancarboxamide	benzimidazoles		low
1-(4-morpholinyl)-2-[2-(phenylmethylthio)-1-benzimidazolyl]ethanone	benzimidazoles		low
2-ethyl-N-[1-[2-(1-piperidinyl)ethyl]-2-benzimidazolyl]-3-pyrazolecarboxamide	benzimidazoles		low
4-[[2-(phenylmethyl)-1-benzimidazolyl]sulfonyl]morpholine	benzimidazoles		low
N-[2-(1H-benzimidazol-2-yl)ethyl]-2-(2-bromophenoxy)acetamide	benzimidazoles		low
N-[(3-methoxyphenyl)methyl]-1-propyl-5-benzimidazolamine	benzimidazoles		low
5-(2,3-dihydroindol-1-ylsulfonyl)-1,3-diethyl-2-benzimidazolone	benzimidazoles		low
N-(2-fluorophenyl)-2-[2-(4-thiazolyl)-1-benzimidazolyl]acetamide	benzimidazoles		low
N-[[4-(diethylamino)phenyl]methyl]-1-[2-(1-piperidinyl)ethyl]-2-benzimidazolamine	benzimidazoles		low
N-[[5-(1H-benzimidazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-5-chloro-2-methoxybenzamide	benzimidazoles		low
5,6-dimethyl-2-[1-[[1-(phenylmethyl)-5-tetrazolyl]methyl]-4-piperidinyl]-1H-benzimidazole	benzimidazoles		low
2-[[5-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide	benzimidazoles		low
2-[[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]methyl]benzonitrile	benzimidazoles		low
2-(2-chloro-3-pyridinyl)-1-prop-2-enylbenzimidazole	benzimidazoles		low
6-(4-methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole	benzimidazoles		low
2-(6-chloro-3-pyridinyl)-1H-benzimidazole	benzimidazoles		low
4-[1-[(3-methoxyphenyl)methyl]-2-benzimidazolyl]-1,2,5-oxadiazol-3-amine	benzimidazoles		low
11-[2-(diethylamino)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrile	benzimidazoles		low
N-[2-(1H-benzimidazol-2-yl)ethyl]-3,5-dinitrobenzamide	benzimidazoles		low
2-[[2-(2-methylphenoxy)ethylthio]methyl]-1H-benzimidazole	benzimidazoles		low
N-[[5-(1H-benzimidazol-2-yl)-2-chloroanilino]-sulfanylidenemethyl]-2,6-dimethoxybenzamide	benzimidazoles		low
3-(1H-benzimidazol-2-yl)-N-(3-pyridinylmethyl)aniline	benzimidazoles		low
3-[3-[[2-oxo-2-(1,2,5-trimethyl-3-pyrrolyl)ethyl]thio]propyl]-1H-benzimidazol-2-one	benzimidazoles		low
2-[[6-(butylsulfamoyl)-1H-benzimidazol-2-yl]thio]-N-(2-chlorophenyl)acetamide	benzimidazoles		low
1-[4-(1H-benzimidazol-2-yl)phenyl]-3-[3-(4-morpholinyl)propyl]thiourea	benzimidazoles		low
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone	benzimidazoles		low
N-[4-(1H-benzimidazol-2-yl)phenyl]-2,3,4,5,6-pentafluorobenzamide	benzimidazoles		low
N-[2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-2-benzimidazol-3-iumyl]ethenyl]-N-methylaniline	benzimidazoles		low
1-(2-chlorophenyl)-3-[[(1-ethyl-2-methyl-5-benzimidazolyl)-oxomethyl]amino]thiourea	benzimidazoles		low
1-[[2-(1H-benzimidazol-2-ylthio)-1-oxoethyl]amino]-3-ethylthiourea	benzimidazoles		low
2-[(6-methyl-1H-benzimidazol-2-yl)thio]-1-(2-methyl-1H-indol-3-yl)ethanone	benzimidazoles		low
2-[(6-chloro-1H-benzimidazol-2-yl)thio]-N-(2,3-dihydro-1H-inden-5-yl)acetamide	benzimidazoles		low
N-(1H-benzimidazol-2-yl)-4-(3-methylphenoxy)butanamide	benzimidazoles		low
N-(1H-benzimidazol-2-yl)-2-methylsulfonylbenzamide	benzimidazoles		low
1H-benzimidazole-5,6-diamine	benzimidazoles		low
N-(4-methylphenyl)-5-nitro-4-spiro[benzimidazole-2,1'-cyclohexane]amine	benzimidazoles		low
1-(2-chlorophenoxy)-3-(2-methyl-1-benzimidazolyl)-2-propanol	benzimidazoles		low
2-phenyl-2,3-dihydro-[1,3]thiazino[3,2-a]benzimidazol-4-one	benzimidazoles		low
2-[[(1-butyl-2-benzimidazolyl)amino]methyl]phenol	benzimidazoles		low
2,2'-[3-(2-methoxyphenyl)-1,2-propanediyl]bis(1H-benzimidazole)	benzimidazoles		low
N-(1-butyl-2-benzimidazolyl)cyclohexanecarboxamide	benzimidazoles		low
1-azepanyl-[2-(phenylmethyl)-1-benzimidazolyl]methanone	benzimidazoles		low
[1-[3-(4-methylphenoxy)propyl]-2-benzimidazolyl]methanol	benzimidazoles		low
1-(2-methoxyethyl)-2-[(4-methoxyphenoxy)methyl]benzimidazole	benzimidazoles		low
4H-[1,3]thiazino[3,2-a]benzimidazol-4-ol	benzimidazoles		low
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)propanamide	benzimidazoles		low
N-(1,1-dioxo-3-thiolanyl)-N-methyl-2-[[1-(2-phenylethyl)-2-benzimidazolyl]thio]acetamide	benzimidazoles		low
7-[[[1-(3-methylphenyl)-2-benzimidazolyl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone	benzimidazoles		low
2-(4-cyanophenoxy)-N-(2-methyl-1-phenyl-5-benzimidazolyl)acetamide	benzimidazoles		low
5-hydroxybenzimidazole	benzimidazoles; phenols	bacterial metabolite; human metabolite; rat metabolite	low
2-[8-(6-amino-1H-benzimidazol-2-yl)octyl]-3H-benzimidazol-5-amine	benzimidazoles		low
2-(2,3,3-trichloro-1-nitroprop-2-enylidene)-1,3-dihydrobenzimidazole	benzimidazoles		low
N-[4-(1H-benzimidazol-2-yl)phenyl]-4-ethoxy-3-nitrobenzamide	benzimidazoles		low
N-[4-(1H-benzimidazol-2-yl)phenyl]-2-methyl-4-nitro-3-pyrazolecarboxamide	benzimidazoles		low
N-[2-[1-methyl-5-[[(4-methylphenyl)-oxomethyl]amino]-2-benzimidazolyl]ethyl]-2-furancarboxamide	benzimidazoles		low
2-[[5-[2-(1H-benzimidazol-2-yl)ethyl]-4-methyl-1,2,4-triazol-3-yl]thio]acetonitrile	benzimidazoles		low
1-cyclopentyl-1-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(2-oxolanylmethyl)thiourea	benzimidazoles		low
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(4-methyl-2-thiazolyl)acetamide	benzimidazoles		low
3,4,5-trimethoxy-N-[2-(1-methyl-2-benzimidazolyl)ethyl]benzamide	benzimidazoles		low
1-(2,4-difluorophenyl)-2-methyl-N-[2-(4-morpholinyl)ethyl]-5-benzimidazolecarboxamide	benzimidazoles		low
[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone	benzimidazoles		low
2-[(1-acetyl-2-benzimidazolyl)thio]-N-(2-methoxyphenyl)acetamide	benzimidazoles		low
N-[[4-(dimethylamino)phenyl]methyl]-1-ethyl-5-benzimidazolamine	benzimidazoles		low
2-[(4-cyano-1-oxo-5H-pyrido[1,2-a]benzimidazol-3-yl)methylthio]propanoic acid	benzimidazoles		low
2-[2-(2-chlorophenyl)-1-benzimidazolyl]-N-(2-propan-2-ylphenyl)acetamide	benzimidazoles		low
N,N,1-triethyl-2-sulfanylidene-3H-benzimidazole-5-sulfonamide	benzimidazoles		low
2-methyl-1-phenyl-5-benzimidazolecarboxylic acid [2-(2-methoxyanilino)-2-oxoethyl] ester	benzimidazoles		low
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]propanoic acid	benzimidazoles		low
1-ethyl-3-[[2-[(1-methyl-2-benzimidazolyl)thio]-1-oxoethyl]amino]thiourea	benzimidazoles		low
6-nitro-3-phenyl-1H-benzimidazole-2-thione	benzimidazoles		low
2-(1H-benzimidazol-2-yl)-5-methyl-4-(phenylmethyl)-4H-pyrazol-3-one	benzimidazoles		low
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone	benzimidazoles		low
N-[2-(4-fluorophenyl)ethyl]-2-[2-(2-hydroxyethylamino)-1-benzimidazolyl]acetamide	benzimidazoles		low
N-(3,5-dichloro-2-pyridinyl)-2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]propanamide	benzimidazoles		low
N-(5-chloro-2-pyridinyl)-2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]acetamide	benzimidazoles		low
1-(1H-benzimidazol-2-yl)-3-cyclohexylurea	benzimidazoles		low
2-[(2,2-dichloro-3,3-dimethylcyclopropyl)methylthio]-1H-benzimidazole	benzimidazoles		low
N-[4-(1H-benzimidazol-2-yl)phenyl]-3-(2,5-dioxo-1-pyrrolidinyl)benzamide	benzimidazoles		low
N-(3,5-dichloro-2-pyridinyl)-2-[(1-phenyl-2-benzimidazolyl)thio]acetamide	benzimidazoles		low
2-[2-(2-chlorophenyl)-1-benzimidazolyl]-N-(2,6-diethylphenyl)acetamide	benzimidazoles		low
N-[1-(1H-benzimidazol-2-yl)-3-(methylthio)propyl]-3,5-dinitrobenzamide	benzimidazoles		low
N-(1H-benzimidazol-2-yl)-3-phenylbutanamide	benzimidazoles		low
4-[2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester	benzimidazoles		low
1-(4-ethylphenyl)-2-methyl-N-(3-pyridinylmethyl)-5-benzimidazolecarboxamide	benzimidazoles		low
2-methyl-1-phenyl-5-benzimidazolecarboxylic acid [2-(3-methylbutan-2-ylamino)-2-oxoethyl] ester	benzimidazoles		low
N-[1-[1-[2-[4-(diethylamino)anilino]-2-oxoethyl]-2-benzimidazolyl]ethyl]-4-methylbenzamide	benzimidazoles		low
N-(1H-benzimidazol-2-yl)-2-nitrobenzamide	benzimidazoles		low
N-(1H-benzimidazol-2-yl)-3-(1-imidazolyl)propanamide	benzimidazoles		low
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(1-ethyl-2-benzimidazolyl)thio]-N-methylacetamide	benzimidazoles		low
N-[[1-(2-phenoxyethyl)-2-benzimidazolyl]methyl]aniline	benzimidazoles		low
N-[2-(2-benzamidoethyl)-1-methyl-5-benzimidazolyl]-2-methoxybenzamide	benzimidazoles		low
3-[5-(diethylsulfamoyl)-1-methyl-2-benzimidazolyl]propanoic acid [2-(3,5-dichloroanilino)-2-oxoethyl] ester	benzimidazoles		low
3-[1-butyl-5-(diethylsulfamoyl)-2-benzimidazolyl]propanoic acid	benzimidazoles		low
1-cyclohexyl-N-(3-methylbutyl)-5-benzimidazolecarboxamide	benzimidazoles		low
5,6-dimethyl-1-octyl-4-benzimidazolamine	benzimidazoles		low
2-[(6-chloro-2-phenyl-1-benzimidazolyl)oxy]acetic acid	benzimidazoles		low
esomeprazole magnesium	benzimidazoles; sulfoxide		low
methiazole	benzimidazoles; carbamate ester		low
flibanserin	benzimidazoles; N-alkylpiperazine; N-arylpiperazine; organofluorine compound	antidepressant; serotonergic agonist; serotonergic antagonist	low
1-ethyl-N-[[1-(phenylmethyl)-2-benzimidazolyl]methyl]-5-benzimidazolamine	benzimidazoles		low
dexlansoprazole	benzimidazoles; sulfoxide		low
ag 14361	benzimidazoles		low
l 779976	benzimidazoles; indoles; piperidinecarboxamide; primary amino compound; secondary carboxamide	neuroprotective agent; somatostatin receptor agonist	low
NNC 55-0396 (free base)	benzimidazoles; cyclopropanecarboxylate ester; organofluorine compound; tertiary amino compound; tetralins	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; neuroprotective agent; potassium channel blocker; T-type calcium channel blocker	low
azd 6244	benzimidazoles; bromobenzenes; hydroxamic acid ester; monochlorobenzenes; organofluorine compound; secondary amino compound	anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
binimetinib	benzimidazoles; bromobenzenes; hydroxamic acid ester; monofluorobenzenes; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
crenolanib	aminopiperidine; aromatic ether; benzimidazoles; oxetanes; quinolines; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
jnj 10191584	benzimidazoles		low
5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile	benzimidazoles		low
zstk474	benzimidazoles; morpholines; organofluorine compound; triamino-1,3,5-triazine	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	low
veliparib	benzimidazoles	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	low
N-[(1S)-1-(1H-benzimidazol-2-yl)-3-(methylthio)propyl]-2-(4-chlorophenoxy)-2-methylpropanamide	benzimidazoles		low
5-[[3-bromo-4-[(2-fluorophenyl)methoxy]-5-methoxyphenyl]methylamino]-1,3-dihydrobenzimidazol-2-one	benzimidazoles		low
(2S,4R)-N-(1H-benzimidazol-2-ylmethyl)-4-cyclohexyl-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-carboxamide	benzimidazoles		low
5-fluoro-2-indolyldeschlorohalopemide	benzimidazoles		low
LSM-33057	benzimidazoles		low
4-(4-chloro-3-nitrophenyl)-N-[2-(5,6-dichloro-1-propyl-2-benzimidazolyl)ethyl]-2-thiazolamine	benzimidazoles		low
1-butyl-2-(2-methylphenyl)-7-propan-2-yl-5H-imidazo[4,5-g]quinoxalin-6-one	benzimidazoles		low
N-[4-(1H-benzimidazol-2-yl)phenyl]-1-[(5-methyl-1H-pyrazol-3-yl)methyl]-3-piperidinecarboxamide	benzimidazoles		low
4-[(6-chloro-1H-benzimidazol-2-yl)amino]benzoic acid	benzimidazoles		low
glasdegib	benzimidazoles; nitrile; phenylureas; piperidines	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist	low
1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]-3-pyridinecarboxamide	benzimidazoles		low
ML240	aromatic amine; aromatic ether; benzimidazoles; primary amino compound; quinazolines; secondary amino compound	antineoplastic agent	low
brd4770	benzimidazoles		low
AZ3451	benzimidazoles; benzodioxoles; nitrile; organobromine compound; secondary carboxamide	anti-inflammatory agent; autophagy inducer; PAR2 negative allosteric modulator	low
tak 491	1,2,4-oxadiazole; aromatic ether; benzimidazoles; carboxylic ester; cyclic carbonate ester; dioxolane	angiotensin receptor antagonist; antihypertensive agent; prodrug	low
N-[4-(6-chloro-5-nitro-1H-benzimidazol-2-yl)phenyl]acetamide	benzimidazoles		low
dabigatran etexilate	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; carboxylic ester; pyridines	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug	low

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Inflammation	0	1	2010	2010	14.0	high	0	0	0	1	0	0
Innate Inflammatory Response	0	1	2010	2010	14.0	high	0	0	0	1	0	0

1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]benzimidazole

Description

Cross-References

Synonyms (13)

Drug Classes (1)

Protein Targets (20)

Potency Measurements

Bioassays (7)

Research

Studies (5)

Study Types

Related Drugs (253)

Drugs in this Class (253)

Related Conditions (2)